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KMID : 0357920120460030292
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Korean Journal of Pathology
2012 Volume.46 No. 3 p.292 ~ p.296
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Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: Report of Two Cases and Review of the Literature
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Kang Young-Ran
Jung Won-Kyung
Do In-Gu
Lee Eui-Jin
Lee Min-Hyeong
Kim Kyoung-Mee
Choi Jong-Sang
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Abstract
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Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a recently recognized entity. Because of its rarity, only 22 cases have been reported in the English-language literature and most of these are single case reports. We report two cases of gastric PAMT. The tumor cells were bland and plexiform arranged in a myxoid stroma, which was positive for alcian blue. Immunohistochemically, the tumor cells were positive for smooth muscle actin, but negative for c-kit, CD34, desmin, S-100 protein, epithelial membrane antigen, neurofilament, and protein kinase C-theta. Mutation analyses for exon 9, 11, 13, and 17 of KIT genes and 12, 14, and 18 of the platelet-derived growth factor receptor alpha (PDGFRA) genes were performed and the tumors were wild-type for mutation.
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KEYWORD
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Angiomyxoid, Stomach, Myofibroblasts, Plexiform, Prognosis, Review
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